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GLP-1 Dosage and Titration Guide

Review common semaglutide and tirzepatide titration patterns so you know what to ask a clinician.

Enter your detailsGLP-1 Dosage and Titration Guide
Weeks 1-40.25 mg weeklyStarter phase
Weeks 5-80.5 mg weeklyCommon first increase
Weeks 9-121 mg weeklyIf tolerated and clinically appropriate
Later1.7-2.4 mg weeklyDepends on product and care plan

This is educational only. Your prescribed dose, concentration, and instructions may differ.

Why GLP-1s are usually titrated

GLP-1 medications are commonly increased gradually to support tolerability. The right schedule depends on medication type, formulation, response, side effects, and clinician judgment.

This is a discussion guide, not a prescription

Dose changes should be made only with a licensed clinician. Compounded and branded medications can have different concentrations, devices, instructions, and safety considerations.

Use the result as context, not a diagnosis.

Save the number, compare it with your goals, and bring it into the Caliber intake. A clinician-reviewed plan can account for medical history, medications, tolerability, and whether online weight-loss care is appropriate.

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